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Week 43 · studies published 19–25 October 2026

  1. JAMA

    Randomised controlled trialHaemodynamics & fluids

    Individualized Cardiac Index–Guided Hemodynamic Therapy in High-Risk Patients Undergoing Elective Major Abdominal Surgery: The PELICAN Randomized Clinical Trial

    individualized cardiac index-guided hemodynamic therapy vs routine hemodynamic therapy

    Primary result

    relative risk 0.9495.1% CI 0.83–1.08 · P = 0.38

    Individualized cardiac index-guided hemodynamic therapy vs routine hemodynamic therapy
    relative risk 0.94 (95.1% CI 0.83–1.08); P = 0.38

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  2. Anesthesiology

    Randomised controlled trialSepsis & infection

    Operating Room Air Filtration-Sterilization and Surgical Infections: The ORACLE Randomized Trial in 110,538 Surgeries

    Active vs identical-looking sham supplemental air sterilization

    Primary result

    odds ratio 0.9895% CI 0.92–1.05 · P = 0.609

    Active purification vs Sham purification
    odds ratio 0.98 (95% CI 0.92–1.05); P = 0.609

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  3. British Journal of Anaesthesia

    Randomised controlled trialPerioperative

    Effect of electrical impedance tomography-guided positive end-expiratory pressure optimisation on postoperative pulmonary complications in laparoscopic colorectal surgery: a randomised controlled trial

    intraoperative PEEP titration guided by electrical impedance tomography (EIT) or a conventional fixed PEEP of 5 cm H2O

    Primary result

    hazard ratio 0.5395% CI 0.33–0.85 · P = 0.009

    EIT-guided PEEP vs fixed PEEP
    hazard ratio 0.53 (95% CI 0.33–0.85); P = 0.009

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